A global study involving 8,438 patients with colorectal cancer linked to Lynch Syndrome has identified strategies that could significantly reduce the risk of cancer recurrence. A cohort from Ahmedabad represented India in the research.
Lynch Syndrome—also known as Hereditary Non-Polyposis Colorectal Cancer (HNPCC)—is the most common hereditary cancer condition, markedly increasing the risk of colorectal and other cancers. In India, the estimated prevalence is approximately 1 in 300 people, and the syndrome is responsible for 10–15% of all colorectal cancer cases, compared to 2–10% in Western countries. The condition is associated with a high relapse rate of 17–50% in later stages.
The findings were published in the British Journal of Surgery (BJS) by Oxford Academic. Dr. Harsh Sheth from the FRIGE Institute of Human Genetics, Ahmedabad, was one of the contributing authors.
“Extended resection reduces the risk of metachronous cancer across all Lynch Syndrome gene groups compared to segmental resection,” said Dr. Sheth. “While neither surgical approach offers a survival advantage, extended resection results in fewer surgeries, lowers surveillance burden, and improves quality of life.”
